Blood Biomarkers for Centenarians

Interesting study on aging:

The Blood of Exceptionally Long-Lived People Reveals Crucial Differences : ScienceAlert

Centenarians, once considered rare, have become commonplace. Indeed, they are the fastest-growing demographic group of the world’s population, with numbers roughly doubling every ten years since the 1970s.

We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards.

Although the median values didn’t differ significantly between centenarians and non-centenarians for most biomarkers, centenarians seldom displayed extremely high or low values.

For example, very few of the centenarians had a glucose level above 6.5 mmol/L earlier in life, or a creatinine level above 125 µmol/L.

For many of the biomarkers, both centenarians and non-centenarians had values outside of the range considered normal in clinical guidelines.

Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea.

That said, chance probably plays a role at some point in reaching an exceptional age.

But the fact that differences in biomarkers could be observed a long time before death suggests that genes and lifestyle may also play a role.

If the cancer and dementia in my family history don’t take me out and civil/WWIII doesn’t make a negative contribution to my health I probably have a higher than average, but far from good, chance at reaching 100.

Worryingly, People Are Defending Themselves

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When a large slice of the public believes that crime is out of hand and most offenses go unpunished, some people inevitably take the law into their own hands.

Worryingly, we’re seeing more signs of that phenomenon in Chicago, with three separate episodes over the last weekend in which would-be victims proved to be both armed and willing to fire at their assailants. Four people who police said were attacking these concealed carry holders were shot and wounded, all of them critically.

But the majority of Chicagoans, we’re convinced, don’t feel any safer when they read stories of good-guy-with-a-gun responses to street crime. They may feel some satisfaction when street criminals feel the same level of fear their would-be victims do. But overall, it’s not a healthy environment in a city — where by definition people live close together — when gun-packing citizens become more the norm than the exception.

This is not to pass judgment on those who for their own protection go through the steps necessary to get a concealed carry permit and then take advantage of the legal rights that license gives them.

Surely, our public officials, no matter what side of the criminal-justice-reform divide they’re on, can agree that the growing risks of more ordinary citizens taking responsibility for their own safety at the point of a gun isn’t a healthy development.

The Editorial Board, Chicago Tribune
June 6, 2024
Editorial: Potential victims are shooting back. This should raise alarms for Chicago public officials. (yahoo.com)

Even ignoring that someone shooting in self-defense is not “taking the law into their own hands”, this is a little warped.

It seems as if they really want to say how bad it is that people can carry guns to defend themselves. And if only public officials would do their job then we could get those icky guns out of the hands of the unclean common people without so much fuss.

Russia Versus America and NATO

I think I found this on X or Gab. I’m just not sure where:

A Russian wife turned to her husband and asked, “What’s this special military operation our glorious leader keeps talking about?” Her husband replied, “It’s a war to stop America and NATO.” “Oh, right” she says “How’s it going?”

“Well” he replied “so far we have lost over 20 generals, 100,000 troops killed, countless injured, 3000 tanks, 300 aircraft, hundreds of helicopters, countless armoured vehicles, artillery and trucks, our flagship along with other naval ships, our army is being defeated in most areas and we have had to resort to conscripting 500,000 Russians including murders and rapists to replace our losses”.

“Wow” replied the wife “what about America and NATO”?

“They haven’t turned up yet”

While not entirely true, there is probably a little too much truth to be funny to the top Russian politicians and the military.

Micropenis Rapid Response Force

Quote of the Day

Holy shit lol the entire Micropenis Rapid Response Force came out to reply to you here

‘Cope! Seethe! 3 inches is big enough!!’

Of the 20 replies you got, there’s gotta be a total of 80 domestic violence charges & *zero* satisfied women between them all

Spaghetti Policy? @alt_DoooooM
Posted on Twitter March 4, 2022

It’s not only another Markley’s Law Monday, it is another science denier (see also here)!

I have to give him a bonus point for the phrase “Micropenis Rapid Response Force”. I have not heard that one before.

And he gets another bonus point for the prejudice of expecting gun owners to be perpetrators of domestic violence.

Via a tweet from In Chains @InChainsInJail.

Worse Than the NRA

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The National Rifle Association is not what it used to be, and that’s created a gap. And what has gone into the gap are a bunch of further-right organizations that are trying to take the mantle of the NRA by being as extreme as possible. Foremost among them is the Firearms Policy Coalition. Friday was a real moment for them. It’s one of the most extreme groups; it uses extraordinarily violent rhetoric. And it’s putting out material that’s getting blessed by a majority opinion of the Supreme Court. You have to take a step back and look at where we are—I don’t think that’s anything you could imagine happening even 10 years ago.

David Pucino
Legal director of the Giffords Law Center
June 15, 2024
The group rewriting America’s gun laws for the Supreme Court Is Worse Than the NRA. (slate.com)

I was already convinced the FPC deserved my support. You don’t need to oversell them.

I know I shouldn’t be surprised but I was amazed at the projection, lies, and deception presented in this interview. Here is an example:

Justice Clarence Thomas’ majority opinion is rooted in historical misrepresentations and utterly implausible manipulations of the statutory text.

The link leads to these claims:

Justice Clarence Thomas’ opinion for the court tortures statutory text beyond all recognition, defying Congress’ clear and (until now) well-established commands.

Thomas adopted a highly technical interpretation of the statute that does not align with its text. A “single function of the trigger,” he wrote, does not mean a single pull of the trigger, but rather a complete “cycle” of the spring-loaded hammer inside the gun. Because the hammer (rapidly) resets to its original position between shots, Thomas concluded, “bump firing” involves more than “a single function of the trigger.”

Deception and lies. It what they do because it is the best they have to bring to the debate.

Death Comes For Them All

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Death comes for them all.

image

Firearms Policy Coalition @gunpolicy
Posted on X June 14, 2024

The ATF rules are different than “assault weapon” bans, but I think the odds are good that SCOTUS will eventually kill them too.

I like the FPC. They work on a lot of 2nd Amendment cases, get decent results so I donate a fair amount of money (matched by my employer) to them each year.

Truth is Hard and Dangerous to the Social Order

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schools should include a class called Truth Is Hard, where u get bombarded with examples of confused eyewitnesses, incorrect public outrages, studies that failed to replicate, super convincing arguments that fall apart with one additional fact u didn’t expect, etc.

Aella @Aella_Girl
Posted on X March 27, 2022

Nice idea. But I don’t think it would ever be accepted in todays K-12 schools. There are far too many people who have false beliefs which they could not tolerate being faced with overpowering evidence of their falsehood. It would disrupt the social order.

At the college level classes which include similar material do, or at least used to, exist. The book Is it really so?: A guide to clear thinking, no longer in print, was used in one of the classes I took in college. It was written by the grandfather (or perhaps great uncle) of one of my college classmates. A few days ago I went looking for it in my library and I could not find it. I’ll look again someday. I remember it as being like a one hour read. I would like to read it again.

By the same author I also had, and perhaps still have, Who Should Have Children?: An environmental and genetic approach. It is still in print. I find it to have the potential to be far more threatening to the social order. But, I expect that is not how the majority of people see it.

Communists Attack the Food Supply

Via Kat@Kataja:

There is probably more truth in this than I would like to admit.

Prepare appropriately.

This evening I spent 2.5 hours on the cat discing my summer fallow in preparation for planting wheat on it this fall. I guess this sort of makes me a farmer.

Things would be “interesting” if the commies in this country attacked the farmers like they did in other countries. I have a rifle and know how to use it. And I know I’m not the only farmer with similar tools and skills.

Wrong Ideas About Poverty

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A comment I am now unable to locate pointed out that fake-working-class trustafarians can be identified by their subscription to a mythical idea of what poverty is.

[this is the comment he was looking for]

The sound of a poor neighborhood in the United States is not the shouts and laughter of children at play, the music floating from the open window of abuela’s kitchen as she makes empanadas, the chatter of men playing dominos on a folding table on sidewalk.

It is the shriek of a child as his single, crack-addict mother beats him, the ceaseless barking of the vicious and unsocialized pitbull in the fenced-off yard, the unmuffled exhaust of the cheap sports car with peeling paint as it pulls up across the way to disgorge a trio of angry drunks.

To this observation, I would add:

The socialist trustafarian’s idealized notion of poverty is drawn not only from Hollywood, but from socialism’s own profoundly wrong ideas about what poverty is and where it comes from.

Middle and upper class socialists think poverty is lack of money.

Thus, whenever they are confronted with a member of the underclass, or, more often, the abstract idea of a member of the underclass, they think he is them, minus money.

And that’s how they expect him to act, right up until the point they get stabbed.

This is also why they think the problem of poverty can be solved simply by taking money from those who have it, and giving it to those who don’t.

Now, at some times, in some parts of the world, this sort of poverty may indeed have existed. When economic conditions are so depressed that great swathes of otherwise-functional people are poor, then they may, indeed, build vibrant, functional neighborhoods with a strong sense of community.

But in a capitalist, or capitalist-adjacent system, that’s not what happens. Sure, becoming wealthy is always hard, and often needs to be a multigenerational process, but capitalist systems do not hold talented, stable, high-agency people in utter poverty for long.

In capitalism, poverty is lack of the ability to secure an income.

This means that poor areas in first world capitalist countries are not filled with cheerful urchins selling newspapers, but with people who have some issue preventing them from being functional wage-earners.

Typically this has to do with mental health, addiction, or life skills. And it means that poor neighborhoods, in, say, the US, aren’t just filled with broke people, they are filled with people who do antisocial things.

You cannot fix this by moving resources around.

And if you subscribe to a mental model (socialism) that ascribes virtue to poor people, and evil to rich ones, then you end up having to do absurd mental gymnastics to try to characterize every prosocial behavior, such as training your dog not to bark, and not running the leaf blower at 0730, to be acktshoeally problematic in some weird way.

The wealth of the wealthy comes from inhabiting a culture, and subculture, where social encounters are a source of opportunities and mutual benefit, rather than conflict. Measurable financial wealth is important, yes, but it is downstream of existing, and functioning, in this sort of high-trust, cooperative, networked society.

Some behaviors of wealthy people are a consequence of wealth. But others are a cause of it, and still others are symptoms of more fundamental attitudes that lead to it.

And one of the major reasons why people buy houses in expensive neighborhoods is so avoid inconsiderate people.

Devon Eriksen @Devon_Eriksen_
Posted on X June 16, 2024

I found this resonated well with my half-baked view of things. I have thought, perhaps, a big problem with very poor cultures was they have a very poor sense of time. In particular, there is no urgency in getting things done.

I have done reasonably well for myself. My station in life, my wealth, my children, my spouse, etc. are significantly above average. I see a fair number of people who have not, and will not, do well in life. In almost all of those cases I can quickly point out a half dozen or more things they could have done or should do, or not do, to make their lives much better. But they can’t seem to do them. They keep making what I think are stupid decisions and blame others for the poor outcomes.

These are simple (to me anyway) things like show up to work on time. Get things done. Don’t use (or use very little) recreational drugs including alcohol and tobacco. Be presentable to your employer and customers. Don’t complain about problems, find solutions to problems and/or get the help of others to implement your solutions and/or help find solutions. Don’t insist on being weird.

Your mileage may vary.

Guilt by Association

Quote of the Day

It’s interesting how gun ownership is the only thing I can think of where many people feel comfortable blaming you or trying to make you feel guilty for the actions of others. Like yesterday, comments to the effect “kids were shot at a water park because you gun nuts won’t give up your toys!”

We don’t do this with anything else.

When a drunk driver wipes out a family (10,000 drunk driving deaths per year!), nobody guilts you for having a couple beers that day. Because they know the drunk driver’s crime does not mean you are irresponsible or criminal. Between all causes, alcohol kills around 2-3x as many people as die in gun-related causes annually.

STDs kill thousands each year, but aside from the very religious, few try to publicly shame the sexually promiscuous for those deaths.

Heart disease kills…more people than anything else. Nobody is protesting at McDonalds.

And guns, while they can be used for monstrous crimes, also have considerable social utility for sport and self-defense.

[and]

There are probably many more examples. Just an interesting phenomenon.

[and]

I should clarify that I mean human activity.

Obviously, people often blame entire cultural, racial, or religious groups for the crimes of one of their own.

Maybe therein lies the answer though. Gun ownership is made into its own sort of caricatured ideological identity by the people who despise it.

That’s wrong of course. As @davidyamane says in his new book, “guns are normal and normal people use guns”.

Kostas Moros @MorosKostas
Posted on X, June 16, 2024

Grouping people makes it easier to demonize all of them by the characteristics of a few. It is an easy “solution” to a difficult problem. Democrats are communists… give them free helicopter rides. Republicans are ignorant… send them to education camps.

I prefer, but certainly contribute my share of inappropriate group shaming, to judge people as individuals.

Words Mean Things

Quote of the Day

There is something reckless in a Supreme Court that can annihilate gun laws by pulling at words, toying with phrases. There are many reasons to think about reforming the higher court. Decisions like this ought to be high among them.

Dominic Erdozain
June 15, 2024
Opinion: Supreme Court’s bump stock decision is a huge step backward (msn.com)

Reading the opinion piece you realize it is Erdozain who “pulls at words and toys with phrases”. Either that, and/or he is ignorant of the topic he writes about. As usual, these people project what they do onto their political enemies.

It is the ATF that thinks it can “annihilate gun laws.” They tried that by saying the law includes a bump stock when the law actually says a machine gun is a gun that fires more than one bullet with a single function of the trigger. The ATF “annihilated” the law and replaced it with their own “law”, which is unconstitutional. Only congress can create or change law. And last Friday, SCOTUS reminded the ATF and the rest of the country of that.

Words mean things. And the ATF must abide by the words of the law. If the law needs to be changed, then persuade congress to do that.  Apparently Erdozain doesn’t understand that is how things are supposed to work. He wants the president to be able to give an order and change the law at will. His desired political system is more like a monarchy or dictatorship. Lots of people agree with him.

Prepare appropriately.

It is No Surprise They Are a Science Denier

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I see you have a tiny penis and want to murder people…

Lord Boofhead (@Lord_Boofhead)
Posted on X June 29, 2023

It’s not only another Markley’s Law Monday, it is another science denier (and here)!

And, is frequently the case, the account is suspended.

Delusions are a sign of mental issues. This candidate for the cuckoo’s nest thinks they can see your penis as well as read your mind. Therefore, it is no surprise they are a science denier.

Does AI Represent an Existential Threat to Humans?

This video was very helpful to me. It probably has me persuaded that AI poses a significant existential threat.

I would present the case as follows:

  • AI will be used for the good of mankind. Examples include:
    • Health care.
    • Food production.
    • Transportation.
    • Energy creation and distribution.
    • Waste removal.
  • AI will be used to develop even smarter AI.
  • We will become dependent upon AI.
  • We will enable AI to protect itself so that it can continue to provide for us even when under attack from others who want to harm us.
  • AI will “realize” we are not needed, in fact, we are a parasite to them.
  • AI will work to eliminate dependencies on
    humans.
  • AI may use our dependencies on them to rid themselves of the parasites.

It wasn’t stated as above, I filled in a lot of blanks and extrapolated. This is one path having the potential to go very badly for us.

There is a minor counterpoint made by my stepson. My stepson has a master’s degree in computer science, specializing in machine learning, AI, etc.. That is the following.

AI has been trained on what is nearly the sum of all human knowledge… the Internet. Machine learning is no better than the data it was trained on. A good portion of the new knowledge, since the best AIs were trained, will be AI generated. If AI can only do almost as good as the data it was trained on, then future AI, trained on AI generated data, will not make as big advances, if any, as previous AI advances.

Error by Anti-Gun SCOTUS Justices

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#2A TERRIBLE ERROR BY ANTI-GUN SCOTUS JUSTICES. Never interrupt your enemy when they are making a mistake. In today’s Cargill/bump stock opinion, the below statement from Sotomayor/Kagan/Jackson will have major implications for AR-15 ban cases. Their dissent reads: “Within a matter of minutes, using several hundred rounds of ammunition, the [Vegas] shooter killed 58 people and wounded over 500. He did so by affixing bump stocks to COMMONLY AVAILABLE, SEMIAUTOMATIC RIFLES.” In my view, this is a devastating legal admission by the left that AR-15s are “in common use” and cannot be banned under Heller/Bruen.

Mark W. Smith/#2A Scholar @fourboxesdiner
Posted on X, June 14, 2024

While I think it is an error on their part, I don’t think the legal implications are as clear cut as Smith implies. His claim presumes the justices will be consistent with previous writings. I could easily see Sotomayor/Kagan/Jackson saying “in common use” when they see that to their advantage as in the bump stock case. If the guns are in common use and easily simulate fully automatic firearms, then commonly available is a bad thing. In a future case, involving an “assault weapon” ban, claiming they cannot be consider in common use because they are less than 5%* of all guns in the U.S. It is “whatever is needed to justify my conclusions”, not what the word of law says, or what I said yesterday.

But, the important thing is that we should celebrate the elimination of the bump stock ban and the slap down on the ATF claiming they can rewrite the law. This is a great precedent and will be useful in many other cases.

In related news, I received a text message from lawyer friend Mike B.:

I find it charming that Sotomayor explains how to bump fire an AR-15 in her dissent. How far we’ve come.


* I asked Copilot, “What percentage of all firearms in the U.S. are of a type similar to the AR-15?” Copilot responded with:

As of the data available, AR-15s and similar semi-automatic rifles, often referred to as Modern Sporting Rifles, account for an estimated 19.8 million units1. Considering the total number of firearms in civilian possession in the U.S. is around 434 million, AR-15 style rifles make up approximately 4.6% of all firearms in the country. This percentage is based on the figures indicating that about 30.2% of gun owners, which is about 24.6 million people, reported owning an AR-15 or similarly styled rifle2. It’s important to note that these numbers are estimates and the actual figures may vary. The AR-15 style rifles have seen a significant increase in production over the years, rising from around one percent of all firearms produced in the early 1990s to almost a quarter in 20203.

Never mind that Copilot’s logic is faulty**. I can’t imagine those justices really care anyway.

** if 24.6 million people own AR-15s, the total number of AR-15 should be at something closer (or greater than) 24.6 million, I think it is unlikely there are 4.8 million people sharing ownership of a rifle which is not canceled out by millions of others owning two (or ten) AR-15s.

Risks of Socialized Health Care

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Thanks to the NHS, all taxpayers are stakeholders in the wider health of our nation. This involvement should make us less tolerant of any section of society creating a healthcare burden through any promotion of ignorance.

Jamie Blackett
June 11, 2024
Vegans are slowly killing themselves (msn.com)

This is just one of the problems with socialized health care. Your “ignorance” becomes the business of the government. And if they decide your decisions about your body are “ignorant” then they claim the moral and legal authority to override your decisions.

The worst case scenario is, of course, when they decide your continued existence it not worth the cost of keeping you alive. But there are lots of other situations where things get ugly. Forced use of insufficiently tested drugs or vaccines. Denial of use of unapproved procedures or medicine even when the patient has nothing to loose.

I realize there are problems with a completely free market, but Jefferson has it right:

I would rather be exposed to the inconveniences attending too much liberty
than to those attending too small a degree of it.

Thomas Jefferson
December 23, 1791
From Thomas Jefferson to Archibald Stuart, 23 December 1791 (archives.gov)

Patience, Luck, and Principles or Burnings at the Stake

Quote of the Day

A little patience, and we shall see the reign of witches pass over, their
spells dissolve, and the people, recovering their true sight, restore their
government to its true principles. It is true that in the meantime we are
suffering deeply in spirit, and incurring the horrors of a war and long
oppressions of enormous public debt…If the game runs sometime against us at home, we must have patience till luck turns, and then we shall have an opportunity of winning back the principles we have lost, for this is a game where principles are at stake.

Thomas Jefferson
June 4, 1798
Letter to John Taylor, in The Writings of Thomas Jefferson p. 1050.

Witches have taken power again. I’m not certain patience, luck, and principles will prevail this time but I dread the burnings at the stake.

What To Do With President Biden?

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Gen. Kurt von Hammerstein-Equord, a noted German military officer and opponent of Adolf Hitler, is said to have categorized leaders on their intelligence and industriousness, noting:

“I divide my officers into four classes as follows: the clever, the industrious, the lazy, and the stupid. Each officer always possesses two of these qualities. Those who are clever and industrious I appoint to the General Staff. Use can, under certain circumstances, be made of those who are stupid and lazy. The man who is clever and lazy qualifies for the highest leadership posts. He has the requisite and the mental clarity for difficult decisions. But whoever is stupid and industrious must be got rid of, for he is too dangerous.”

Applying von Hammerstein-Equord’s classification to contemporary politics, some critics argue that Biden, in his current state, fits in the “stupid and lazy” category. This combination, while not ideal, allows for the possibility of stage management by staff, competent or otherwise. Though our system of government expects a vigorous executive — as Alexander Hamilton noted in Federalist 70, “energy in the executive is the leading character in the definition of good government.” Today, we have no energy in the White House. 

But while the president’s vacuous passivity can be navigated with a degree of difficulty, Vice President Kamala Harris’s vigorous foolishness is a bigger threat. This perspective, along with Harris’s historically low approval ratings, is likely why the Biden cabinet hesitates to invoke the 25th Amendment to remove Biden from office — they’re stuck with no good options.

But even were Newsom to replace Biden on the Democratic ticket, America remains under grave threat from the dangers of a mentally declining president.

Chuck DeVore
June 11, 2024
Biden’s mental decline jeopardizes national security. Democrats have one card left to play (msn.com)

Interesting observations. I have observed all those types in co-worker over the years. The stupid and industrious were the most annoying. I called them “enthusiastically stupid”.

On Hunter Biden’s Conviction

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“No single action can solve the entirety of a gun violence epidemic,” he said. “But together, our efforts–your efforts–are saving lives. You can help rally a nation with a sense of urgency and seriousness of purpose. You’re changing the culture. And we’ve proven we can do more than just thoughts and prayers. This is more than thoughts and prayers. You’re changing politics.”

President Biden then departed for his hometown of Wilmington, Delaware, where earlier today his son Hunter Biden was found guilty of three gun-related felony charges.

T.J. Muscaro
June 11, 2024
Biden Touts Measures to Curb Gun Violence | The Epoch Times

Oh, the irony… Smile

Some people expect President Biden will pardon his son. If he does, I don’t think it will be until after the election in November. I think a more likely scenario is the appeal will result in some narrow ruling which gives Biden, and only Biden, a pass.

In only the most unlikelist of circumstances will Biden’s appeal result in overturning existing gun law on Second Amendment grounds in such a way that it will benefit the average gun owner.

Also note President Biden claims gun control is saving lives, but they never supply the evidence to back up such claims.